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Sohan Chitlange ¹, Sagar Pandkar ¹, Mukund Tawar ¹, Sagar Wankhede ¹

Affiliations
1 Padm. Dr. D.Y. Patil Institute of Pharmaceutical sciences and Research, Sant Tukaram Nagar, Pimpri, Pune-411018, Maharashtra, IN

Abstract

Two UV spectrophotometric methods have been developed for simultaneous estimation of salbutamol sulphate (SAL) and ambroxol hydrochloride (AMB) in combination using distilled water, hydrochloric Acid (0.1N) and phosphate buffer (pH 6.8) as solvent in bulk as well as in tablet formulation. Method I employs formation and solving of simultaneous equation using 224.5 nm (λmax for Salbutamol) and 244.5 nm (λmax for Ambroxol) as two analytical wavelengths for both drugs in distilled water, hydrochloric acid (0.1N) and phosphate buffer (pH 6.8). Method II involves area under curve method, wavelength range selected are 229.5 nm-219.5nm for salbutamol and 249.5nm-239.5nm for ambroxol respectively. Beer's law was obeyed in the concentration range of 4-24 μg/ml and 10 - 60 μg/ml for salbutamol and ambroxol respectively. The methods were validated statistically for accuracy, precision and recovery studies which show no significant difference between the results obtained by the two methods for analysis of salbutamol and ambroxol. The wide linearity range, sensitivity, accuracy, and simple procedure imply that the proposed technique demonstrated to be appropriate for determining assay of both the drug component simultaneously and for dissolution study to find out invitro release rate in tablet formulation.

Keywords

Salbutamol Sulphate, Ambroxol Hydrochloride, Simultaneous Equation Method, Area under Curve Method.

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Vishal Mahanur ¹, Rahul Rajge ¹, Mukund Tawar ¹

Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604, IN

Abstract

The initial pass metabolism or pre-circulatory system is a metabolic process in which the concentration of the drug is significantly reduced or shortened in the liver before it reaches the circulatory system. A fraction of the drug lost in the entire absorption process is often associated with the liver and skin wall. Oral delivery, the simplest form of drug management has its limitations, most of which are the low availability of drugs due to the first internal organ passing through metabolism. Drugs with low bioavailability need to be administered at a better dose as a small fraction of the controlled dose is injected into the bloodstream and reaches the target. Therefore, the worst dose of the drug is destroyed and the unauthorized drug ends up having unwanted side effects within the canal. Various forms of oral contraceptives are used. The current review focuses on the importance of passing the first hepatic pass, the biological findings, the reasons for the negative findings and the various methods used to skip the initial hepatic pass metabolism.

Keywords

Hepatic First Pass Metabolism, Bioavailability, Novel Drug Delivery System, Low Bioavailability, Gut Wall, Site Targeted

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Kalyani Gudadhe ¹, Mukund Tawar ²

Affiliations
1 Department of Quality Assurance, P.R. Pote Patil College of Pharmacy, Amravati – 444604, IN
2 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604, IN

Abstract

A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1%. Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20μl.The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Rupatadine Fumarate were performed (10-60μg/ml). The %RSD for accuracy found to be less than 2%. Assay was found to be 99.17 to 101.65 respectively. The range of 10-60μg /ml was selected for the linearity of a standard Rupatadine Fumarate. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study. Linearity studies for Rupatadine Fumarate was performed on (10-60μg/ml).

Keywords

RP-HPLC, Rupatadine Fumarate, Methanol, Ortho Phosphoric Acid

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Rahul Jodh ¹, Mukund Tawar ¹, Prashant Burange ¹, Vedanshu Malviya ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602, IN

Abstract

In The family Orchidaceae, The plant Dactylorhiza hatagirea (D.Don) Soo, is recognized worldwide for its multi-fold benefits. Dactylorhiza hatagirea (D.Don) Soo Traditionally it used to cure various diseases like dysentery, diarrhoea, chronic fever, cough, stomach-ache, wounds, cuts, burns, fractures, general weakness. Dactylorhiza hatagirea (D. Doon) Soo frequently known as Hatajari and Salampanja in the region of Himalaya. Dactylorhiza hatagirea (D. Doon) Soo is a terrestrial orchid found in moderate climate in the alpine and sub-alpine region Indian Himalaya from 2800-4200 m above from sea level its Occurrence also present in Pakistan, Afghanistan, Nepal, Tibet and Bhutan In India, it predominantly found in region of Jammu and Kashmir, Sikkim, Arunachal Pradesh, Uttarakhand and Himachal Pradesh. Dactylorhiza hatagirea (D. Doon) Soo is collected chaotically from nature due to its high economic demand. the plant consist of different active compound which are responsible for various activity attributed on the plant. the present review emphasis on pharmacological activity of Dactylorhiza hatagirea (D. Doon) Soo which is establish by different authors.

Keywords

Dactylorhiza hatagirea (D. Doon) Soo, Himalayan Orchid, Salam Panja, Metformin

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Rahul Jodh ¹, Mukund Tawar ¹, Aparna Kachewar ¹, Vishal Mahanur ¹, Yash Sureka ¹, Virendra Atole ¹

Affiliations
1 Department of Pharmacology, P. R. Pote Patil College of Pharmacy, Amravati-444604., IN

Abstract

The liver assumes a significant part in keeping up with the metabolic capacity and discharge of poisons from the body. A physical issue or liver brokenness brought about by the utilization of poisonous synthetics, over-the-top liquor and microorganisms bring about a difficult condition called hepatotoxicity. Madhuca longifolia having a place with Sapotaceae family is found to have pharmacological properties in the treatment of different disorders. Madhuca longifolia is likewise considered a therapeutic tree also, is helpful for outside application in treating skin infections, stiffness, migraine, persistent clogging, heaps, hemorrhoids, and ethno clinical properties like antibacterial, anxiolytic qualities, anticancer, hepatoprotective, antiulcer, antihyperglycemic, pain-relieving exercises, and so on. Leaves of mahua are utilized in the treatment of dermatitis, wound mending, anti-burn, bone crack, anthelminthic, emollient, skin illness, stiffness, and cerebral pain. The flowers are used as a tonic, pain-relieving, and diuretic; bark for an ailment, persistent bronchitis, and diabetes mellitus and leaves as an expectorant and constant bronchitis and Cushing's sickness. In this review we make a compilation focused on the synonyms, botanical description, phytochemicals, pharmacological activity, and medicinal uses of Madhuca longifolia.

Keywords

Madhuca longifolia, Pharmacology, Anti-anxiety, Phytocompounds, Utilization.

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Rahul Jodh ¹, Mukund Tawar ², Kiran Gomkale ², Sakshi Jari ², Jafer Toply ², Nawed Faisal ²

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602.
2 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN

Abstract

The structural isomer of the tetracycline family is doxycycline. It's a semi-synthetic medication with antibacterial properties against a wide range of germs and excellent intracellular penetration. Bacterial resistance can take many different forms, although the ribosomal or plasmid pathways are the most common. Propionibacterium acnes has gained antibiotic resistance in most cases due to an ARNr mutation. Doxycycline has antiinflammatory effects that manifest themselves through a variety of methods. Doxycycline is quickly absorbed and practically fully absorbed in the GI tract. Food does not affect absorption. With 90% of the molecule attached, it has a strong but fragile affinity for proteins. The majority of tissues and the extravascular compartment are swiftly absorbed. The most common method of excretion is through the bile canal. The bile channel is used for elimination. Tubular reabsorption in the kidney slows down. If you have acne, the daily dosage should be between 50 and 100 micrograms. Despite the scarcity of high-quality assays, there is widespread professional support for their use. It is also effective for rosacea at the same dosage. Doxycycline is being used as a backup antibiotic for chlamydial and mycoplasma urethritis. Additional diseases that can be treated as primary or secondary alternatives include treponematoses, brucellosis, pastoralizes, borreliosis, rickettsiosis, and cholera. Some non-infectious illnesses have been treated with doxycycline. The most common side effects are those that affect the digestive system. Esophageal poisoning has been treated with tablets and plenty of water.

Keywords

Antibiotics, Doxycycline, Tetracycline, Anti-microbial, P acne, Yersinia pestis.

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Rahul Jodh ¹, Mukund Tawar ¹, Aparna Kachewar ¹, Yogiraj Ingole ¹, Tejas Deshmukh ¹, Vipul Ijapure ¹

Affiliations
1 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati., IN

Abstract

Tobramycin is another aminoglycoside anti-microbial with a wide antibacterial range in vitro, and pharmacokinetic properties like those for gentamicin. Tobramycin is more dynamic than gentamicin against Pseudomonas aeruginosa and dynamic against numerous gentamicin safe strains, yet isn't dynamic against enterobacteriaceae impervious to gentamicin. Hypothetically, tobramycin enjoys an upper hand over gentamicin against diseases brought about by P. aeruginosa, yet any benefit in clinical practice presently can't seem to be enough illustrated. Clinical involvement in tobramycin is significantly not exactly with gentamicin. While tobramycin seems to offer no unmistakable benefits over gentamicin against touchy organic entities it is shown in contamination brought about by strains of P. aeruginosa which are impervious to gentamicin, yet touchy to tobramycin. Like gentamicin, tobramycin acts synergistically with carbenicillin and the cephalosporins. The viability of the tobramycin-carbenicillin blend has been displayed in endocarditis brought about by P. aeruginosa which was lethargic to gentamicin in addition to carbenicillin. Ototoxicity and nephrotoxicity like that seen with other aminoglycosides have been experienced in helpful preliminaries with tobramycin and more extensive clinical experience is important to decide the general occurrence of these incidental effects with gentamicin and tobramycin utilized under comparable conditions. Antimicrobial movement: In relative examinations, in vitro, tobramycin is more dynamic than gentamicin against clinical separates of Pseudomonas aeruginosa. Likewise, the inhibitory file, which is the proportion between the serum fixations accomplished at common remedial portions and the base inhibitory focus, for Pseudomonas aeruginosa is higher for tobramycin than for gentamicin.

Keywords

Antibiotic, Tobramycin, Aminoglycoside, Anti-microbial, Pseudomonas aeruginosa

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Mukund Tawar ¹, Kiran Raut ¹, Reshma Chaudhari ¹, Nikita Jain ¹

Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604., IN

Abstract

Orally directed medications totally ingest just when they show reasonable dissolvability in gastric medium and such medications shows great bioavailability. The solvency and disintegration properties of medications assume a significant part during the formulation development. Greater part of the disappointments in the new medication improvement have been credited to poor water dissolvability of medication. It is widely accepted that poor water dissolvability is quite possibly the most every now and again experienced troubles in the field of pharmaceutics. Low solvency and ensuing unacceptable disintegration rate regularly bargain oral bioavailability. There are most remedial specialists used to create fundamental impacts by oral course that are the favored method of organization inferable from its few benefits and high quiet consistence contrasted with different courses. Thusly the current methodologies being utilized for BCS class II medications, along with retention enhancers, can be applied to detail class IV compound. Effervescent Assisted Fusion Technique, Solvent Evaporation method, Microemulsion, Liposomes are some imperative methodologies regularly utilized to improve the dissolvability of ineffectively water dissolvable medications. Determination of technique for solvency upgrade relies on drug qualities like dissolvability, substance nature, melting point, retention site, actual nature, pharmacokinetic conduct, etc, measurement structure necessity like tablet or capsule formulation, strength, quick or modified release. This review features the novel strategies accessible for improving solvency, disintegration and bioavailability of medications with poor fluid dissolvability.

Keywords

Solubility Enhancement, Drug Release, Nanocrystallization, BCS, Novel Techniques.

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Vedanshu Malviya ¹, Mukund Tawar ², Prashant Burange ³, Rahul Jodh ³

Affiliations
1 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN
2 Department of Pharmaceutical Chemistry, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN
3 Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444602., IN

Abstract

Resveratrol can be recognized as a best nutraceutical. Resveratrol is a novel nutraceutical in which not many details are known therefore an attempt was made to review the details which may be used for the further research. Resveratrol is known to be a polyphenol named as stilbenoid group which is a phytoalexin secreted by more than 70 plant species which is having many pharmacological activities like anticancer, anti-inflammatory, anti-ageing, neuroprotective, cardioprotective, anti-microbial and etc. This natural table top food has a lower bioavailability with lower aqueous solubility. From this review we can conclude that resveratrol is a unique complex having various properties with lots of other benefits.

Keywords

Resveratrol, Natural Phenol, Phytoalexin, Grape Skin, Stilbenoid.

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Mukund Tawar ¹, Kiran Raut ¹, Reshma Chaudhary ¹, Nikita Jain ¹

Affiliations
1 Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604., IN

Abstract

The basic reason behind this study was to enhance the solubility rate of resveratrol which will finally enhance the dissolution i.e. the rate of drug release due to which the absorption of the drug will increase. The method applied here was effervescent assisted fusion technique. Various batches were prepared by employing water soluble carrier and sodium bicarbonate. The results obtained from the study revealed that the solubility of the drug can be increased up to 10 times than compared with the pure drug in various solvents i.e. phosphate buffer and distilled water. The compatibility study showed no interaction between drug and the excipient while the micromeretics property showed good flow property with good compressibility property. The percent yield of the dispersions prepared ranges between 79.20±0.28% - 89.38±0.25% while the drug release data showed a better rate of drug release than compared with the pure drug which ranges between 10.87% - 99.14%. The pure drug was having a drug release of less than 70% while the optimized batch F5 was having a drug release of more than 95% in the specific period of time. The XRD data showed that the drug’s crystalline structure was not hampered during the preparation while the SEM data revealed the surface shape of the pure drug which was tile shaped and the prepared dispersion was of flakes like formation. From the study it can be concluded that the methods employed in this study can be proven to be a excellent method for enhancing the solubility of the drug up to 10 folds.

Keywords

Resveratrol, Effervescent Assisted fusion technique, Solubility, Drug Release, Crystals.

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